Accelerate biomedical R&D

Promising science does not always translate into a blockbuster

Translating a promising discovery into a new drug or therapy is a costly, lengthy and risky process, with an average cost of $2.3 billion and an average development time of 15 years.

One of the key factors influencing this process is target identification and validation. Advanced IT solutions and Artificial Intelligence (AI) are playing a transformative role in drug discovery and development by accelerating processes, enhancing efficiency and enabling novel approaches.

15yrs

Time to bring a drug to the market

$2.3bn

The average R&D investment

90%

High attrition rate results in only 10% of drugs reaching the market

Challenges in drug discovery

As pharmaceutical and biotech companies strive to accelerate drug discoveries, whilst incorporating big data and various AI tools, major obstacles still persist:

Causation identification
The process of determining the cause-and-effect relationship by understanding how a drug or intervention impacts specific molecular or biological mechanisms influencing a particular biological outcome or disease progression.

Navigation of complex data sets
The systematic exploration and analysis of intricate datasets, often involving diverse biological, chemical, and clinical information, to derive meaningful insights and inform decision-making processes in drug development.

Programming knowledge required
The necessity for proficiency in coding languages and computational skills to manipulate and analyze large-scale biological and chemical data, facilitate algorithmic modeling, and enhance the efficiency of research and development processes.

Research in silos bounding collaboration
The compartmentalization of scientific endeavors and data within isolated departments or teams, hindering the seamless exchange of information and collaborative efforts essential for holistic advancements in drug discovery and development.

Correlation is not Causation

Causation identification
Determining the cause-and-effect relationship

Current discovery solutions utilising knowledge graphs and NLP technology possess limited capabilities in capturing, analysing and modeling explicit causal relationships of events and processes.

Example: Compound ethanol upregulates incidents of liver cancer:

The above example demonstrates an implicit cause-effect relationship, but that may not be the primary cause of the problem. Examination of details is required.

bigRing’s solution for explicit causation identification

The innovative approach is powered by a proprietary causal graph (bigRing Causality Model™️, cause-effect graph) which enables modelling opposed to programming algorithms.

This universal semantic and metaheuristic model explicitly expresses knowledge understandable for machines.
Its uniqueness lies in reality interpretation that is common across all disciplines. Thus allowing knowledge/information sharing even on higher level of concepts.

By dynamically linking all available information bigRing supports a comprehensive and speedy capture of explicit causal relationships within a multi-dimensional interconnected dataset.

Transform Knowledge to Wisdom

Navigation of complex data sets
Exploration and analysis of intricate datasets

In drug discovery and validation processes complex data sets harder to navigate, leading to decision paralysis and risks of errors.

bigRing’s Solution:

Unified Data Integration

Incorporates data from various structured, semi-structured, and unstructured sources into a unique bigRing graph (bigRing Causality Model™️), helping streamline the assessment process of target identification and validation.

Real-time Data Analysis

Displays knowledge in the form of causal flows, in varying degrees of detail and in different context (according to the user’s point of view), by employing features such as filtering, sorting, real-time target recommendation and validation reasoning.

Error Identification and Correction

Ensures data completeness, identifies potential errors in the data import model or source, and allows for manual correction.

Easily accessible technology

Programming knowledge required
Coding languages and computational skills

Technical/coding knowledge is required to extract and manipulate data from various sources.

bigRing’s Solution:

No-code solution

Empowers scientists with automated workflow solutions without the need for intricate programming.

Customizable Visualization

Supports customization of the knowledge graph according to users interests, highlighting specific pathways or elements.

User-Friendly Interface

Allows researchers to select preferred data sources and areas of interest without needing extensive IT expertise or support.

Unlock the Synergy

Research in silos bounding collaboration
Compartmentalization of scientific endeavors and data.

In the realm of scientific research, collaboration and validation by peers are indispensable.

bigRing’s Solution:

Enhanced collaboration & peer review

Promotes seamless collaboration among scientists on the same topic, allowing for real-time feedback, shared insights, and a more efficient research progression.

Presentation of outcomes

The bigRing graph with different levels of granularity facilitates easier presentation of findings at conferences or in journals, for gathering observations from a wider scientific community.

Integration with advanced algorithms

A researcher can easily generate outputs by utilizing AI for textual formulations to help reduce cognitive burden and save time.

Overall benefits of bigRing’s platform

Strengthened target identification & validation

Productivity gains and cost reduction

Time to market

BigRing’s solutions in the biomedical field help speed up scientific processes and discovery by reducing research time, improving accessibility for non-programmers, and encouraging collaboration. Its cloud-based AI software for knowledge accumulation, including the unique bigRing Causality Model™️, simplifies complex system causation modelling.

This potential accelerates solutions and product discovery in precision and network medicine.

Precision Medicine Activities

We attended the RexPo23 conference

How to Start Collaborating with Us

We welcome inquiries from pharmaceutical and biotech companies, as well as researchers and scientists in the biomedical field.

1
Consultation
Once you have contacted us, our team will schedule a consultation to discuss your specific needs and requirements. During this consultation, we will identify the challenges you are facing in drug discovery and development and determine how our services can assist you.
2
Service Offering
After understanding your needs, we will provide you with a comprehensive overview of our services and solutions. Our offerings include advanced IT solutions and Artificial Intelligence (AI) tools that accelerate processes, enhance efficiency, and enable novel approaches in drug discovery and development.
3
Tailored Approach
We understand that each client has unique requirements. Therefore, we will work closely with you to tailor our services to meet your specific needs. Whether you require target identification and validation, navigation of complex datasets, programming assistance, or enhanced collaboration, our team will develop a personalized approach for you.
4
Implementation
Once you have chosen the services that align with your goals, we will begin the implementation process. Our team will guide you through each step and ensure a seamless integration of our solutions into your research and development processes.
5
Continuous Support
Our collaboration does not end with implementation. We are committed to providing ongoing support to our clients. Our team will be available to address any questions or concerns that may arise, and we will work together to achieve your desired outcomes.

Competence

Our team of experts will walk you through the process and highlight in which ways our solutions can tailor fit your specific needs. Our services are offered both on a monthly and annual subscription basis, providing flexible plans for companies of all sizes.

We understand that each customer’s needs are unique. This is why we provide personalized technical assistance and tailored offer, depending on factors like the amount of data, computational capacity, types of specific algorithms, software libraries and integrations.

Software

To start, we’ll set you up with a cloud account on BigRing Consulting Platform™. This provides an isolated enterprise cloud account accessible immediately after the request is approved. Alongside, you can choose between Admin, Expert-User, End-User, IoT/API or Community Accounts, depending on your specific needs.

For a more focused analysis, we offer the bigBrain Intelligence Engine™. This service features intelligence computing automation which assists in everything from AI computing tasks to operating instance processes.

Added Value

Whether you’re searching for ways to reduce research time, boost collaboration or improve accessibility for non-programmers, bigRing is equipped to empower your technical team in their mission for accelerating biomedical R&D.

By partnering with us, you can accelerate your biomedical R&D, overcome challenges in drug discovery, and unlock the full potential of advanced IT solutions and AI tools. Contact us today to start collaborating and revolutionize your research and development processes.

MUDr. Ivan JurášScientific Director

Mgr. Vladimír Heger PhD.bigRing Biomed R&D

Please contact us to receive a detailed case study on how BigRing supported identification of Metformin’s impact on Amyotrophic lateral sclerosis (ALS)

Connect with us

Our dedicated team is always ready to schedule a live demonstration.

Accelerate biomedical R&D

Promising science does not always translate into a blockbuster

Challenges in drug discovery

Correlation is not Causation

bigRing’s solution for explicit causation identification

Transform Knowledge to Wisdom

bigRing’s Solution:

Easily accessible technology

bigRing’s Solution:

Unlock the Synergy

bigRing’s Solution:

Overall benefits of bigRing’s platform

Precision Medicine Activities

How to Start Collaborating with Us

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